TZD Safety

There's a very reassuring study showing safety of thiazolidinediones, a class of diabetes drugs. The two brand names of drugs in this class are Avandia and Actos. This study looked at a whole bunch of reports and so-called "open label clinical studies." (These are studies done when people know which drug they are taking). Over almost 10,000 person-years of people taking these drugs, there continues to be an excellent safety profile.

This is reassuring because, as you might remember, a few years ago one of the drugs in this "TZD" class had a greater level of hepatic disease or liver toxicity. This analysis, with a huge number of people, shows that these drugs really are safe.